Word: functionally
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Dates: during 2000-2009
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...surprise. That gene's activity affects the junction between nerve cells, where various neurochemicals work to relay signals from one nerve cell to another. While most of the research attention in Alzheimer's has been on the build up of amyloid protein and tau tangles that strangle nerve function, the identification of PICALM suggests that some part of the disease may have to do with a breakdown in nerve-cell communication at the junctures. "If you had given people a list of genes and said which ones were involved in late onset Alzheimer's disease, PICALM would have been less...
...says Dan Reinberg, a partner at Polsinelli Shughart PC. He adds that government entities have sovereign immunity for good reason. "The regulators are there to do a job that the public has asked them to do, and if they can be sued for negligence or mismanagement in their official function, then who's going to want to be a regulator?" he asks...
...test whether their lab-made cells could function like normal beta cells, Melton's group exposed them to glucose in a dish. When sugar levels were high, the cells produced more of a protein that beta cells release when they break down sugar; when glucose levels were low, the protein levels were low as well. (See pictures from an X-ray studio...
...before that can happen, says Melton, the newly formed beta cells can become a valuable resource for understanding Type 1 diabetes better - to answer key questions such as what makes the cells so ineffective in diabetics, and whether new populations of beta cells could survive and function if transplanted into patients. "This is opening a door to a long-term project to get at the cause of this disease," he says. "But it is a new door...
...don’t have much confidence given the way American capital markets function that they can effectively govern companies,” said Lorsch...