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...August, a team of scientists at Northwestern University were the first to show why the brain's "memory function" fails in the face of an insulin shortage. The group's prior research had already pinpointed the culprit: toxic proteins called amyloid beta-derived diffusible ligands (ADDLs, for short), which are known to pile up in the brains of people with Alzheimer's. Scientists also knew that Alzheimer's patients' brains have lower levels of insulin and are insulin resistant. But what the Northwestern team discovered is the molecular mechanism behind that resistance: when ADDLs bind to neurons at synapses, they...

Author: /time Magazine | Title: Is Alzheimer's a Form of Diabetes? | 10/18/2007 | See Source »

...understand that the function of insulin at those synapses is to modulate and influence the underlying cellular structure of memories," says William Klein, professor of neurobiology and physiology at Northwestern University and a co-author of the study published online by the FASEB Journal. "What we have here is a striking phenomenon that may ultimately explain why the brains of people with Alzheimer's disease are insulin resistant and how that ties into memory...

Author: /time Magazine | Title: Is Alzheimer's a Form of Diabetes? | 10/18/2007 | See Source »

Swamiji's message, delivered in part via that transcendental software, PowerPoint, and some well-placed jokes, is that stress is not a function of external demands--the number of employees and dollars to manage, e-mails to answer, strategic plans to complete or loved ones to placate. Stress is internal, he insists. Make a rational assessment of your situation with all its requirements and flaws--consider, for instance, the past behavior of your customers, your colleagues, your spouse--adjust your expectations accordingly, and the stress will vanish. He gives some quick examples. "I'm in New York. There will...

Author: /time Magazine | Title: Swami, How They Love Ya | 10/18/2007 | See Source »

...tribunal next. Her wrap dress was inspired by “the original metropolis”... Ancient Greece? The judges were particularly wowed by her craftsmanship and praised the “pure form” of her ensemble. The main attraction for Mueller, however, was not form or function, sexiness or metropolicity, but rather the striking colors and utility of the dress...

Author: By Nicola C. Perlman and Nicole G. White, CRIMSON STAFF WRITERS | Title: Competition: Metropolitan | 10/17/2007 | See Source »

...Iraq, Bush accepted responsibility for the activities of military contractors like Blackwater, which is under investigation on Capitol Hill and in Baghdad for its use of force in Iraq. But he split the difference on defending them, saying they were performing a useful function there and praising their "sacrifice", while saying he would be "anxious to see the analysis of their performance" in Iraq...

Author: /time Magazine | Title: Bush's New Shades of Gray | 10/17/2007 | See Source »

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