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...Translational Genomics Research Institute are doing just that. Relying on the ABA, Stephan has identified a group of genes involved in age-related memory loss and has developed five compounds that mimic the activity of the genes. At least three of the new compounds appear to enhance memory function in aging rats...

Author: /time Magazine | Title: The Brain: What The Mouse Brain Tells Us | 1/19/2007 | See Source »

...practice session, they sat beneath a coil of wire that sent a brief magnetic pulse into the motor cortex of their brain, located in a strip running from the crown of the head toward each ear. The so-called transcranial-magnetic-stimulation (TMS) test allows scientists to infer the function of neurons just beneath the coil. In the piano players, the TMS mapped how much of the motor cortex controlled the finger movements needed for the piano exercise. What the scientists found was that after a week of practice, the stretch of motor cortex devoted to these finger movements took...

Author: /time Magazine | Title: The Brain: How The Brain Rewires Itself | 1/19/2007 | See Source »

When the scientists compared the TMS data on the two groups--those who actually tickled the ivories and those who only imagined doing so--they glimpsed a revolutionary idea about the brain: the ability of mere thought to alter the physical structure and function of our gray matter. For what the TMS revealed was that the region of motor cortex that controls the piano-playing fingers also expanded in the brains of volunteers who imagined playing the music--just as it had in those who actually played...

Author: /time Magazine | Title: The Brain: How The Brain Rewires Itself | 1/19/2007 | See Source »

...DECADES, THE PREVAILING DOGMA IN neuroscience was that the adult human brain is essentially immutable, hardwired, fixed in form and function, so that by the time we reach adulthood we are pretty much stuck with what we have. Yes, it can create (and lose) synapses, the connections between neurons that encode memories and learning. And it can suffer injury and degeneration. But this view held that if genes and development dictate that one cluster of neurons will process signals from the eye and another cluster will move the fingers of the right hand, then they'll do that and nothing...

Author: /time Magazine | Title: The Brain: How The Brain Rewires Itself | 1/19/2007 | See Source »

...research in the past few years has overthrown the dogma. In its place has come the realization that the adult brain retains impressive powers of "neuroplasticity"--the ability to change its structure and function in response to experience. These aren't minor tweaks either. Something as basic as the function of the visual or auditory cortex can change as a result of a person's experience of becoming deaf or blind at a young age. Even when the brain suffers a trauma late in life, it can rezone itself like a city in a frenzy of urban renewal...

Author: /time Magazine | Title: The Brain: How The Brain Rewires Itself | 1/19/2007 | See Source »

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