Word: fusions
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...fusion of a mature Ellen overcoming her basement nightmare and the precocious adolescent Ellen is both fresh and hauntingly familiar. There are the echoes of another spunky Dutch girl that get the reader's imagination working overtime. What sort of chronicle of deaths foretold would Anne Frank have written if she had survived Bergen-Belsen, returned to Amsterdam and moved back to her secret quarters at 263 Prinsengracht...
...David Ho, director of the Aaron Diamond AIDS Research Center in New York City, "because cell membranes can present barriers to some drugs, and some have molecules that pump out drugs that manage to get inside." This suggests that the new drugs might be effective at lower doses, making fusion inhibitors safer for the patient in the long run. Trimeris' studies support this; so far, neither of its compounds seems to cause any of the serious toxic side effects associated with today's AIDS drugs, such as nausea, vomiting and abnormalities in fat metabolism...
Trimeris' compound, called T-20, blocks the final structural contortion from taking place. For this reason it and a second candidate, T-1249, are known as fusion inhibitors. Progenics has been testing a different type of entry inhibitor, a molecular decoy for CD4 whose job is to find, bind and lure HIV away from the real CD4 cells...
...early promise of the fusion inhibitors bears out, they will be a welcome and badly needed addition to the HIV drug arsenal. For while the available antivirals have had a dramatic impact in reducing the death rate from AIDS, they are not enough. As more patients take these cocktails of powerful drugs for more and more years, the dual problems of resistance and toxicity are beginning to tarnish the promise they once held...
...half the time, on East Meets West, Tsai cooks expert fusion fare. The other half, on his new food-adventure show Ming's Quest, he's diving for sea urchins, falling off horses or staring down alligators like the Crocodile Hunter. Likewise, Bobby Flay and Mario Batali have taken their chef stars on the road in their own travel series. As Tsai puts it, "The network wanted to get us out of the kitchen." The few remaining hard-core cooking shows succeed because they have a gimmick, like Sara Moulton's stump-the-chef call-in show Cooking Live...