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...drugs provided relief to 60% to 80% of patients, but they also caused serious side effects, including sluggishness, weight gain and occasionally death from overdose. The ground was ripe for a better pill, and it wasn't long before scientists produced a new, highly targeted class of antidepressants, led by Prozac, which hit the U.S. market in 1987, followed by Zoloft in 1991 and Paxil in 1992. Instead of blanketing a broad range of brain chemicals, the drugs - known as selective serotonin reuptake inhibitors (SSRIs) - zeroed in on one: serotonin, a critical compound that ferries signals between nerve cells. SSRIs...

Author: /time Magazine | Title: Antidepressants | 1/7/2010 | See Source »

...most that Republicans can hope for is to regain control of the House and pick up a net gain of five seats in the Senate. But in order to achieve this, Republicans must unify their fractured party, and given the spate of conservative primary challenges, from Mark Rubio in Florida to Rand Paul in Kentucky, this will be no easy task. The tea-party movement is also making life difficult for new recruits like Griffith, who after switching parties now faces a tough primary. And the GOP is plagued by cash woes. After spending heavily in the Virginia...

Author: /time Magazine | Title: Senate Retirements Point to Dems' Uphill Election Fight | 1/7/2010 | See Source »

...frozen foods sounds less serious; in a 500-calorie entree, after all, 8% adds only 40 calories. That, however, is in a single meal. Over the course of a year, consuming just 5% more than you need in a 2,000-calorie diet can mean a 10-lb. weight gain. "The 18% and 8% figures are just what you need not to lose weight," says Roberts. (See the best pictures...

Author: /time Magazine | Title: Dieters Beware: Calorie Counts Are Frequently Off | 1/6/2010 | See Source »

...November, with some 17% of the center-left electorate now saying they have a positive opinion of the center-right prime minister. The same survey, however, showed a disturbingly high - more than 20% - number of respondents approving of Tartaglia's attack. (Read "The Berlusconi Attack: Will Italy's Leader Gain Sympathy...

Author: /time Magazine | Title: Can Berlusconi Get His Game Face Back On? | 12/31/2009 | See Source »

...ensure that the pro-smoking movement doesn't gain any more ground, authorities may have to do just that. Even though there are costs associated with enforcement, the government will probably still come out ahead -officials estimate that the state spends about $15 billion a year treating smoking-related illnesses. Stamping out a few butts could amount to very little in comparison...

Author: /time Magazine | Title: Smoking Ban? The French Light Up Again in Public | 12/26/2009 | See Source »

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