Word: gallos
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...York family, is a list of victims' relatives?young men orphaned by contract, brothers bound to avenge a family murder?who would like to see Colombo killed. His rise in the Mob hierarchy has also earned him the bitter enmity of former comrades, notably Joseph ("Crazy Joe") Gallo, onetime Profaci triggerman whom Colombo opposed during a bloody gang war in the early...
...enzyme associated with Temin's discovery was at first believed to be unique to cancer cells infected by viruses. Thus when Columbia University's Sol Spiegelman and the National Cancer Institute's Robert Gallo found high enzyme activity in the cells of leukemic patients, medical science had a solid clue that leukemia might be caused by a virus. Even more important, some researchers speculated that if the Temin enzyme was found only in cancer cells, the spread of cancer might be halted simply by inhibiting the enzyme...
Carefully examining the white blood cells of 48 healthy people and three leukemia patients, Gallo and two colleagues−Stringner S. Yang and Robert C. Ting of the Bionetics Research Laboratories−discovered a small but possibly critical difference. The white cells of the leukemia victims showed the presence of an enzyme known as RNA-dependent DNA polymerase; the cells of the normal people did not. The presence of the enzyme suggested that it may play a key role in the development of the disease...
Deadly Message. Gallo's hypothesis tends to support the iconoclastic ideas of Howard Temin, a University of Wisconsin molecular biologist who long espoused what his colleagues considered a major heresy. According to accepted theory, the hereditary information in the chromosomes of all cells passes in the same direction. Double-stranded DNA molecules make single-stranded messenger RNA molecules, which then direct the production of proteins, the basic building blocks of every cell. Temin contended that the process is sometimes reversed: RNA, he insisted, could make DNA. Otherwise, he asked, how could cancer-causing viruses−which consist of bundles...
...Gallo and other investigators are already searching. One likely candidate is an antibiotic called N-dimethylrifampicin. This chemical has already proved effective in the laboratory in inhibiting the activity of the suspect enzyme. In the future, such chemicals may be able to work their magic...