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According to Aster, normal NOTCH1 gene activity is essential for T-cells, which defend the body against disease, to mature. The NOTCH1 gene is mediated by a critical molecule called gamma secretase...

Author: By Risheng Xu and Jennifer XIN-JIA Zhang, CRIMSON STAFF WRITER AND CONTRIBUTING WRITERS | Title: Researchers Find Possible Cure For Type of Leukemia | 10/12/2004 | See Source »

...patients with T-cell acute lymphocytic leukemia, the NOTCH1 gene is mutated and gamma secretase keeps the gene turned on, leading to T-cell overproduction and eventually leukemia...

Author: By Risheng Xu and Jennifer XIN-JIA Zhang, CRIMSON STAFF WRITER AND CONTRIBUTING WRITERS | Title: Researchers Find Possible Cure For Type of Leukemia | 10/12/2004 | See Source »

According to Aster, stopping the effects of the gamma secretase would bypass NOTCH1’s abnormal activity, thus stopping the cancer from progressing...

Author: By Risheng Xu and Jennifer XIN-JIA Zhang, CRIMSON STAFF WRITER AND CONTRIBUTING WRITERS | Title: Researchers Find Possible Cure For Type of Leukemia | 10/12/2004 | See Source »

Drug companies are now developing gamma secretase inhibitors in an effort to help Alzheimer’s patients...

Author: By Risheng Xu and Jennifer XIN-JIA Zhang, CRIMSON STAFF WRITER AND CONTRIBUTING WRITERS | Title: Researchers Find Possible Cure For Type of Leukemia | 10/12/2004 | See Source »

...gamma-ray and neutron spectrometers Will detect types of elements on Mercury's surface and within its crust...

Author: /time Magazine | Title: The Hot Rock: Mysterious Mercury | 8/9/2004 | See Source »

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