Word: gauntlet
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Dates: during 1980-1989
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Greater cooperation between the FDA and pharmaceutical companies is the key to the new plan. Before a drug can be approved in the U.S., its manufacturer must guide it through a gauntlet of testing, moving from basic laboratory experiments through animal research to carefully controlled experimentation on people. Under the system in use until now, FDA investigators did not begin evaluating the evidence until the human trials were almost finished. If the research methods or the results did not meet FDA requirements, pharmaceutical companies had to perform more testing, sometimes starting all over again. Now manufacturers...
...thing the debate made abundantly clear is that the negative tone of campaigning is unlikely to let up until the election. In the battle of testy one-liners, Dukakis was the initial and consistent aggressor from the moment he threw down the gauntlet by saying, "If Bush keeps it up, he's going to be the Joe Isuzu of American politics." While Bush immediately countered that one of Dukakis' answers was "as clear as Boston Harbor," he generally avoided such frontal attacks, although he continued his indirect assault on Dukakis over emotionally charged values issues...
...streets of America's cities have become desperate crossroads. To walk any distance at all is to run a gauntlet of beggars of every imaginable description with every conceivable need. Some passersby do not believe their stories; others just do not believe in giving handouts. But even those who once unfailingly reached out to any outstretched palm now find themselves overwhelmed and unsure: To give or not to give? In Manhattan, where the beggars are legion, the sheer weight of their number and the volume of their appeals have set the city on edge. "New Yorkers feel besieged...
Phantom, then, is the gauntlet that Lloyd Webber has thrown down to challenge his critics to take him seriously. As lush and ornate as the Paris Opera in which it is set, Phantom is the composer's most elaborate, beguiling score. It is also the most frankly operatic, not only in its parodies of period works by such composers as Salieri and Meyerbeer but in the way it has been written. Like an opera, Phantom is almost entirely sung, and its characters are outfitted with sharply etched musical motifs. Except for the title song, there is no rock music...
...season, when city streets are filled with shoppers and tourists. "There is no contradiction between feeling sad because you don't know how to help and being frightened because one of the people asking for help may hit you on the head," says Michael Zeik, 64, who runs a gauntlet of beggars at New York City's Grand Central Terminal on his frequent visits to Manhattan from his suburban home...