Word: genentech
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...have the national recognition of a Genentech or Cetus, but Chiron Corp., a small genetic-engineering firm (1987 sales: $20 million) in Emeryville, Calif., has had more than its share of biotech success. Two years ago, a preparation it developed with New Jersey-based Merck to ward off the liver-damaging effects of hepatitis B became the first genetically engineered vaccine to win Food and Drug Administration approval for use in humans...
Scientists are proceeding cautiously with the new therapies. "In any substance that is immunologically active," observes Genentech's Sherwin, "you run the risk of tilting the balance in an unfavorable way. We don't know all of the answers...
...complex organ of them all, the brain. "The immune system has a phenomenal ability for dealing with information, for learning and memory, for creating and storing and using information," explains Immunologist William Paul of the National Institutes of Health (NIH). Declares Dr. Stephen Sherwin, director of clinical research at Genentech: "It's an incredible system. It recognizes molecules that have never been in the body before. It can differentiate between what belongs there and what doesn...
...raged over two main points: whether the drug increased the survival rate of heart-attack victims, and whether its benefits outweighed the risks. T-PA's tendency to induce bleeding caused strokes in a number of patients. The agency then asked the drug's developer, south San Francisco-based Genentech, to provide further data...
...which is already sold abroad, will be marketed under the brand name Activase. Genentech officials say the drug, which costs about $2,000 a treatment, could be available in two or three weeks...