Word: genes
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Dates: during 2000-2009
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...three new genes, known as clusterin, complement receptor 1 (CR1) and PICALM, were uncovered by two separate research groups, one in Wales and one in France, who linked the genes to the most common form of the memory disorder, late-onset Alzheimer's - the type that affects patients in their 60s or later and accounts for about 90% of all Alzheimer's cases. The only other gene connected with the condition, apolipoprotein E (ApoE), was identified in 1993; since, researchers have tirelessly hunted for other key genes, knowing that 60% to 80% of the progressive, incurable disease is genetically based...
...Stylistically, the movie is so modest that notable stars, like Affleck and Gene Simmons - who gives a frighteningly vivid performance as an ambulance-chasing lawyer - barely register as themselves. When Affleck cameos for indie director Kevin Smith, there's a lot of fussing, as if there's a "Thanks, Ben!" banner hanging behind him. Judge's take is a welcome contrast. It's the character actors who get to shine here. Koechner is grotesquely right as Nathan, and Saturday Night Live graduate Wiig is far more appealing and nuanced than the sweatpant routine would suggest. Collins, practically unrecognizable...
...researchers divided the group into three: those who had no risk factors for Alzheimer's, those who had a family history of the disease but no genetic indicators of it themselves and those who had both family members with Alzheimer's as well as a version of a gene for a protein called apolipoprotein E4 (ApoE4) that has been linked to the condition. They slid all of the subjects into an fMRI machine, and while the volunteers were there, they saw names of both famous and not-so-famous people flashed in front of them. (See the Top 10 Medical...
While doctors can now test for the presence of ApoE4, you have to have two copies of a particular form of the gene to be at real risk of Alzheimer's. If you do have them, your chances of developing the disease increase 10- to 20-fold. So far, the Alzheimer's Association does not recommend widespread screening for the gene, even among those with a family history of Alzheimer's, since most people who have the risky version of ApoE4 don't have the necessary gene copies. But looking more closely at people who have a family history...
Fundamentally researchers do not dispute the fact that biology - namely genetics - helps determine individual health outcomes. But the practice of categorizing patients by race has yet to further the discovery of significant gene mutations. What's more, say critics, it promotes racial thinking while dismissing the more germane issue of socioeconomics. Indeed, Albain and her coauthors used a single, widely disputed metric in their study - patients' zip codes linked to census tract data - to "adjust" for socioeconomic status. Yet researchers know that people living within one zip code can include the city's wealthiest and poorest residents. And even...