Word: geneses
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The finding centers on a group of genes known as the Sir2 family. According to Sinclair, research over the last several years suggests the Sir2 gene plays an important role in regulating aging.
The researchers, led by HMS Associate Professor of Pathology David A. Sinclair, published a paper last month in the journal Science that detailed a finding they believe sheds new light on the role of genes in regulating aging.
But the new finding by the HMS researchers—who included Dudley Lamming, Oliver Medvedik, and Magda Latorre-Esteves, in addition to Sinclair—reveals that Sir2 does not serve this function alone. Rather, a group of related genes—the Sir2 family—plays a...
Sinclair said that he and his fellow researchers are in the process of establishing the individual purpose of each gene in order to determine which ones can be used for medicines. They are currently using one of the genes in the Sir2 family to protect mice from brain disorders analogous...
The discovery of the Sir2 family came about after researchers realized that even organisms that did not contain the original Sir2 gene could have their lifespans extended by calorie restrictions, Sinclair explained. “These other genes take over,” he said.