Word: geneses
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What Simons calls the "Dresden model" has certainly worked for Cenix. The company's team of 26 scientists uses a technique called gene silencing, a procedure that selectively disables (or silences) individual genes. Once a specific gene--in a mouse, for example--has been silenced, researchers can determine that gene...
Before Christophe Echeverri decided to spin his postdoctoral project into a biotech company called Cenix BioScience in 1999, he hesitated, fearing the switch from lab coat to business suit was a "move over to the dark side." Echeverri had been invited to turn the research he was doing at the...
At the University of California, San Francisco, meanwhile, molecular geneticist Cynthia Kenyon is taking a different approach to aging research, identifying a number of genes in roundworms that help stave off disease and extend life. One such gene directs the action of a receptor for insulin and an insulin-like...
But the story is more complex: Kenyon has found that hormones in her long-lived worms actually regulate several unusual genes to increase life-span. One set of genes triggers the worms' cells to make antioxidants, which fight off the ravages of molecules called free radicals, which can damage DNA...
Johnston doesn't dwell on what age has taken away from her. "She's never been a complainer," says Julie. That attitude may have much to do with her prodigious longevity. Not to mention good genes and a whopping dose of good luck. Johnston's father, a Presbyterian minister, died...