Word: geneses
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They went to Gene Logic because the company is one of a handful, along with California's Affymetrix and Incyte, that have developed DNA-chip and microarray technology--in this case, chips that can monitor some 42,000 genes in one shot--and software to analyze the results. Using these...
The findings are now being prepared for scientific publication, and thus can't be revealed in detail. But Gene Logic will say that based on the genes active in this patient's cancer, antiangiogenesis drugs and most chemotherapy wouldn't work but three drugs would. Moreover, the scientists discovered that...
The strategy clearly works. Last October scientists at Glaxo Wellcome announced that their patient database and SNP mapping information had yielded four genes that were promising drug targets: one each for Alzheimer's, diabetes, psoriasis and migraine. "We've already done what people are proposing to do in the future...
The actions of individual genes, moreover, make a lot more sense in the context of other genes. "Right now," says Stanford biochemist Patrick Brown, "it's like watching a movie on TV a few pixels at a time and trying to figure out the overall story. Having the complete genome...
Why not study all the proteins? For one thing, there are too many--50,000 to 2 million, depending how you count. For another, most of those millions of proteins are just variations on a handful of themes. Proteins with similar functions--be they in insect, worm or man--often...