Word: giacomini
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Dates: during 2000-2009
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...everyone could understand it. It is not easy and simple to face that change in our life, but we must accept it without falling into depression. It is true that with therapy and medical help things can really change and we can look at life through different eyes. Adriana Giacomini Donato Colloredo di Prato, Italy
...known to play a role in drug absorption and elimination. The first step is to look at the genes for those transporters in DNA samples from 250 ethnically diverse people and see how they vary from one individual to the next. "Identifying the variants is rather easy," says Kathleen Giacomini, the project's principal investigator and UCSF's chairwoman of biopharmaceutical sciences. "The really hard part is in looking at whether the variants have significance for drug response...
...response to a particular body chemical--serotonin, for example, a neurotransmitter implicated in clinical depression--varies. Then they bathe the cells in Prozac, for instance, which works by modifying serotonin levels in the brain, and see how that response changes. "If there's a difference," says Giacomini, "I'll know that maybe your transporter interacts with the drugs a little differently from mine...
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