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Similarly, Harren Jhoti left pharmaceutical giant Glaxo Wellcome (now GSK) in 1999 when he realized that his unconventional idea of how to find new drugs to attack disease-causing proteins might never be realized unless he pursued it himself. He founded Astex, based in Cambridge, England, so he could develop his own flexible approach to molecular research. He calls it "fragment based," because rather than throwing an entire proposed drug molecule at the target protein, he throws just pieces at a time...
...crystal technique revealed that a chemical was binding to a protein that is a possible cause of Alzheimer's disease. The chemical was a fragment of what could eventually become an Alzheimer's-conquering drug. "I first thought the team had played a trick on me," says Jhoti. Drug giant AstraZeneca, which had been searching for such a chemical for years, enlisted Astex's help. In 2003 the company signed a contract to pay Astex $40 million if Astex hits milestone breakthroughs and to make royalty payments once AstraZeneca sells drugs based on Astex's technology. "AstraZeneca worked...
...writer's most persistent misunderstandings comes over the term otaku, which typically describes fans so devoted that they all but lose touch with the rest of the world. Carey sees a metaphor for the otaku in the characters of Mobile Suit Gundam?kids who fight battles from inside giant robots, alienated from everything outside them. As Charley interacts more fluently with the ticket machines on the Tokyo subway than with the people around him, it's not hard to understand what Carey fears. But he's wrong again?a writer for Gundam explains that the kids inside the suits aren...
...decade ago, Whitefield, a remote suburb of Bangalore, made headlines on those rare occasions when gangs of armed bandits burst into homes at night. Today that former stretch of farmland and scattered houses is disturbed only by giant cranes, cement mixers and trucks piled up with white sand. Buildings of glass and steel are rising all over, as Bangalore's fast-expanding outsourcing industry radiates far beyond the city. Perhaps the most impressive spot in Whitefield is the campus of SAP Labs. The main building, with its comfortable sofas and a sunny atrium, is a sumptuous workplace by Indian standards...
...what is most remarkable about that site, built by the German software giant SAP, is what's going on inside. SAP Labs' 1,400 employees in Bangalore form the company's largest research-and-development unit outside Germany. Instead of dumping its call-center work and low-end programming in Whitefield, SAP relies on the area's computer scientists and engineers to carry out its most critical activity. More than 10% of the patents filed by SAP originate in Bangalore, and the influx of Indian engineers is accelerating the adoption of English at SAP and loosening up its traditionally rigid...