Word: giovannucci
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...tomato products, and lycopene, don't affect all prostate cancers equally, but may instead help slow the growth only of aggressive and late-stage prostate tumors. "There is some evidence that it's at the later stages of prostate cancer where lycopene might be most relevant," says Dr. Edward Giovannucci, professor of epidemiology and nutrition at the Harvard School of Public Health and principal author of the 2002 study. "But with PSA tests picking up cancers earlier, we may not be able to see that benefit...
...later-stage aggressive tumors emerged. But in post-PSA studies, this association weakened, since fewer men went on to develop the aggressive, advanced form of the disease. "I'm still as enthusiastic about the hypothesis [that tomato products can reduce prostate cancer] as I was five years ago," says Giovannucci. "We just need to figure out a way to do better, more definitive studies to understand how it works...
...high BMI “has been associated with a higher risk of many cancers, but the studies have not been so consistent for prostate cancer,” said Associate Professor of Medicine Edward L. Giovannucci ’80, the study’s lead author...
...understanding the causes of prostate cancer better, we hope to eventually be able to offer more in terms of prevention,” Giovannucci said...
...been shown in other studies that obesity in men is related to lower androgens levels so we hypothesize that this may account for the relationship we’ve observed,” Giovannucci said. “We need to do more studies in which we directly measure androgens levels in men, along with BMI, and assess simultaneously their association with prostate cancer...