Word: globulin
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Dates: during 1960-1969
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What the hemophiliac's blood lacks, because of a genetic defect transmitted from mother to son, is a clotting protein known as antihemophilic factor (AHF) or globulin (AHG), also called Factor VIII. Because of this deficiency, the hemophilia victim lives in constant danger of severe bleeding from the most minor wound, such as a finger cut or a tooth extraction. Even with no external injury, he may bleed internally after a bump or a stumble. This is especially likely to happen inside his joints, causing arthritis with progressive deformity and disability...
Starzl stopped operating while he and his colleagues worked on a less hazardous method of immunosuppression, using antilymphocyte serum or globulin extracted from horses into which human white blood cells had been injected (TIME, July 26). Only when the technique was developed satisfactorily did he begin transplanting again. In his second series, Starzl operated last year on Julie Rodriguez, now 21, who suffered from cancer of the liver. Julie has had to be readmitted for additional treatment, but has now survived for a record twelve months. Starzl has no hope of curing her cancer, which has spread. What is certain...
...Star. The area of deepest ignorance and most hopeful new reports covered the problem of protecting the implanted heart against rejection. Here the star turned out to be not a surgeon but a drug, forbiddingly named antilymphocyte globulin...
...after five years of testing, a new blood extract called RhoGAM has arrived on the market. It enables doctors to protect each subsequent child by merely inoculating the mother. RhoGAM consists of a gamma-globulin fraction rich in Rh antibodies. Injected into the Rh-negative mother's bloodstream no later than three days after a miscarriage or the birth of her first Rh-positive child, it curtails her immune mechanism's production of antibodies and lessens the danger to future Rh-positive children. The inoculation must be repeated after each miscarriage or birth, but the tests show that...
...Jacques Gottlieb, of Detroit's Lafayette Clinic, told a tale of three laboratories: Lafayette, the Massachusetts' Worcester Foundation for Experimental Biology, and the Soviet Academy of Sciences' Institute of Psychiatry. Independently, each had discovered increased amounts of a component of the alpha-2-globulin fraction in the blood of schizophrenia victims. Alpha-2-globulin is a normal part of blood plasma, containing many proteins. In the blood of 60% of the schizophrenics studied by Gottlieb, the fraction was present at far-above-normal levels. The excessive alpha-2-globulin, Gottlieb theorizes, may perforate brain-cell walls...