Word: globulin
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Dates: during 1960-1969
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...disease takes the form of a deficiency in antihemophilic globulin--Factor VIII. In normal humans the Factor VIII level in the blood stream ranges from 50 to 200 per cent. Hemophiliacs generally have a Factor VIII level of less than 25 per cent...
...patients-who had died of some cause other than a liver disease. Before implantation, the donated liver was matched for tissue and blood cells. To further assure a reasonable chance of success, Starzl and his colleagues gave their young patients injections of azathioprine (Imuran), prednisone and antilymphocyte globulin-all of which help to suppress immune reactions. The antilymphocyte globulin, newly developed from the blood of horses that have reacted to human tissue, is already helping to improve the chances (now estimated at 65%) of successful kidney transplantation as well...
...glands, spleens and lymph nodes are removed from human cadavers, and the extract is injected into horses. The horses' rejection mechanism goes to work and makes particles active against the human lymphocytes. The horses are later bled, antilymphocyte serum is extracted, and may be further refined to a globulin fraction. At the University of Colorado, a team headed by Dr. Thomas Starzl has performed 19 successful transplants since last June; given antilymphocyte globulin, the patients have got along well on sharply reduced doses of azathioprine and prednisone...
...could be combined. Couldn't the pooled substance be used to make a vaccine that would work on victims of various forms of cancer? Cancerous cells were thereupon collected from patients all over the country and put through an extraction process. The remaining protein was combined with gamma globulin from rabbit serum in the hope of producing an all-purpose vaccine. The trouble with this imaginative theory is that so far there is no accepted evidence for the existence of such widely effective antigens in unrelated cancers...
...blood will be sent to South Vietnam in the form of gamma globulin which is injected into all servicemen to protect against an epidemic of infectious hepatitis. Whole blood will not be sent to South Vietnam...