Word: globulin
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...fevers and rashes all too similar to symptoms of the natural disease. The killed virus vaccine was almost reactionfree, but it might not provide as long-lasting immunity as the live virus. Even with a double inoculation-a shot of live virus in one arm, a shot of gamma globulin containing measles antibody in the other-every fifth child still ran a disturbing fever...
Purple Danger. Fred Wallace had been a bleeder since birth. The absence of AHG (antihemophilic globulin) from his blood taught him early to live with danger. Every childhood spill, every bloody nose, was agonizingly slow to heal. The scrapes and scuff marks of a growing boy remained for weeks as ugly, purple discolorations under the skin. But Fred, like most hemophiliacs, survived all such crises. Then the disease caused other problems. Last spring, on a Sunday outing, Fred and his father had walked away from their parked car so that Fred might snap a picture. Inexplicably, the car started rolling...
...John F. Enders (TIME cover, Nov. 17, 1961) at Children's Hospital Medical Center in Boston. It is immediately available and is highly effective. But in many children, it causes some fever and a rash, so many pediatricians will simultaneously give the child a shot of gamma globulin in the opposite arm. This lowers or eliminates the fever. Merck will distribute the gamma globulin with the vaccine...
Virologists, pediatricians and public health officials have worked out a compromise. They give the live vaccine, and at the same time they give an injection of human gamma globulin, the blood fraction that contains antibodies against measles as well as against other diseases. The "GG" has staved off fever in all but about 20% of children already double-vaccinated and has eliminated the rash in all but 3%. Most important, the GG does not keep the children from developing enough of their own antibodies to give them lasting protection against natural measles...
...week, after much toil by Enders and others, a group of Pennsylvania physicians and virologists announced that they had successfully tested a measles vaccination technique. Children are first inoculated with Enders vaccine, which gives nearly 100% protection. Then, almost immediately, they are injected in the same arm with gamma globulin, which holds undesirable side effects, such as fever and rash, to a minimum. The Public Health Service still must approve the new measles technique, establish manufacturing standards. If all goes well, a vaccine will be on the market next year, just as measles heads toward its next cyclical peak...