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Scientists have suspected that FRMP exerts its braking action by attaching to receptors on the surface of brain cells, known as mGluR5 receptors (the Glu is for glutamate, a key signaling agent in the brain). They reasoned that it would be possible to correct the excesses of Fragile X by blocking these receptors, which act as accelerators of protein production. To test this idea, the researchers produced a special breed of mice that had the Fragile X trait but only half the normal number of mGluR5 receptors. The result, explains Bear: "We were able to correct the excesses [of Fragile...

Author: /time Magazine | Title: A New Approach to Correcting Autism | 12/19/2007 | See Source »

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