Word: gobind
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Like the sages of his native India, Organic Chemist and Nobel Laureate* Har Gobind Khorana is an extremely patient man. Nine years ago, he began working on the chemical synthesis of a single gene-the basic unit of heredity. By 1970 he had constructed a yeast-cell gene identical to the original-except for one thing: it lacked the vital "start" and "stop" signals to make it function in a living cell. Last week members of Khorana's team at the Massachusetts Institute of Technology disclosed that his goal had finally been achieved. At an American Chemical Society meeting...
Five years before the triumph of the Harvard group, Organic Chemist Har Gobind Khorana, a Nobel laureate now working at M.I.T., had synthesized a yeast gene, the simplest gene yet made. Already aware of the sequence of the 77 "code letters," or nucleotides, in the DNA of the gene, Khorana painstakingly "assembled" the letters one at a tune in the proper order to produce a synthetic unit. The rabbit gene is at least eight times as large, containing about 650 nucleotides strung together in a sequence that scientists have not yet completely determined. Clearly the Harvard group could not follow...
...other hand, the research by the Harvard team basically adds to reseaach done by a number of other teams at the National Institute of Health and several universities. Bacterial genes were chemically synthesized in 1973 by an MIT team led by Har Gobind Khorana; Nobel Prize Winners Dr. Howard Temin at the University of Wisconsin and David Baltimore at MIT first discovered the enzyme--reverse transcriptase--that was a keystone in the Harvard research; and three research groups--including one led by Baltimore--simultaneously produced one of DNA's two strands...
...Gobind Khorana, 51, a 1968 Nobel...
Endless Variety. At the University of Wisconsin, a group headed by a distinguished Indian-born molecular biologist, Har Gobind Khorana. 47, reported that it had achieved the first artificial synthesis of a gene-the basic unit of heredity in the nuclei of all cells. Although genetic material has been made in the laboratory before, scientists have always had to use at least some natural cellular material in the process. The Wisconsin achievement marks the first time that a single gene has been created entirely out of off-the-shelf chemicals...