Word: goldstein
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Dates: during 1980-1989
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Wise is successful both as confused and somewhat dippy Baker in the first play and as Banquo in the second. Paul Goldstein is convincing in serious roles in both plays: Polonius/Laertes in the first and Duncan/Macduff in the second...
According to students Richard Goldstein and Lori Kaplowitz '85, the hour-long morning tutorial is only the start of a schedule that each day includes lectures, labs, and afternoon sessions in clinical care. Somewhere between case studies, lab benches, and figuring out how to give a physical; students must find time to independently research the problems they raised in the tutorial session...
Their prize had been predicted for some time, and with good reason: the discovery of the LDL receptor has revolutionized scientists' knowledge of cholesterol metabolism and certain cardiovascular diseases. Says Goldstein: "We now understand the mechanism through which diet and exercise can help prevent a heart attack...
Brown and Goldstein began their pioneering work while investigating severe familial hypercholesterolemia, a rare inherited disorder. Children with the disease have blood-cholesterol levels six to ten times normal and can suffer heart attacks as early as age two. By comparing skin cells from victims with those of healthy people, the two scientists traced the problem to an absence or deficiency of LDL receptors, proteins that stud the outer membranes of most cells, particularly those of the liver. Then they decoded the complex minuet that takes place between the receptor and its LDL particle. Says Baltimore: "That was important...
Brown, 44, is from New York City and married; Goldstein, 45, was born in Sumter, S.C., and is single. The two scientists are close friends. "We've seen each other just about every day for the past twelve years," says Brown. "We had better get along." -- By Natalie Angier. Reported by Bill Bancroft/Dallas...