Word: goldstein
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Dates: during 1980-1989
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...block cholesterol synthesis. In 1976, after testing 10,000 compounds, Endo found one that inhibited a key enzyme in the cholesterol-manufacturing process. Researchers at Merck soon discovered similar compounds, including lovastatin, but the finds would have remained research oddities without the Nobel-prizewinning work of UTHSCD's Joseph Goldstein and Michael Brown...
...travel to docks called LDL receptors. More important, they learned that low cholesterol levels in the liver trigger the production of more receptors, which pull LDL out of the blood. But if the liver does not make enough receptors, the LDL levels in the blood will rise. The trick, Goldstein and Brown theorized, was to stimulate the receptors, thus reducing cholesterol levels...
...unflaggingly avid barnyard animals. You could catch perhaps a dozen commercials for call-girl "escort services" and for Steve, a gaunt guy who poses in his undies, gives his pertinent measurements and phone number and caters to all comers. You could hear the show's executive producer, Al Goldstein, mouth off on any subject that grazed his mind: Gloria Steinem ("great legs"), a play he'd seen in London ("Skip it. Miss it. Crud"), health violations at local restaurants. On Midnight Blue and other sex shows, for the basic cable subscription price, you could watch all this and more...
...Goldstein is one of thousands of Mexicans in towns and cities along the 2,000-mile U.S. border engaged in the lucrative and rapidly expanding business of providing health care for Americans. In Tijuana alone (pop. 1.3 million), there are 18 plastic surgeons and a range of other specialists among some 2,000 registered doctors and 1,700 dentists. Their listings take up 44 pages in the city telephone directory. From a simple dental filling to major reconstructive plastic surgery to a cataract operation, almost every health need imaginable is available just across the border. A major part...
Many Americans are surprised by the range and quality of Mexican health care. "I was very dubious at first about coming here for dental work," recalls Mark Hamilton, a San Diego telecommunications consultant who came to Goldstein in Tijuana in 1983 for root-canal treatment. "But now I am convinced that not only is it cheaper, but also I am getting superior dentistry. They care more down here." He recalls once Goldstein even picked him up at the San Ysidro border crossing in her own car and dropped him off again after the appointment. Says...