Word: gonadotropins
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...Francisco Giants, who a few years ago had Barry Bonds on the roster, how the constant scrutiny can distract a team. There will be taunting on the road. The fans will be wielding some nasty signs: Ramirez reportedly may claim that he took a banned drug called human chorionic gonadotropin to cure erectile dysfunction (the female fertility drug also happens to elevate testosterone levels, which get drained by, coincidentally, steroid use). "Manny Being Mini," one clever columnist has already written. Maybe you just want to send a message, enough is enough with these guys we can no longer trust...
...treatments that delay physical maturity are being seen as a lifesaving alternative for gender-variant kids, but the remedy is also generating medical and ethical questions about interfering with the natural development process. The treatment--a series of injections to interrupt the brain cascade that launches puberty by regulating gonadotropin-releasing hormone (GnRH)--has not yet been submitted for FDA approval for gender-variant children. But it is available from international physicians and some U.S. doctors prescribing off-label. In February the first U.S. clinic for gender-variant children opened at Children's Hospital Boston. Throughout the process of delaying...
Researchers don't know exactly how a child's body decides to start the two-to-three-year process of becoming a biological adult. But they do know the first stage begins in the brain, when a chemical signal, called gonadotropin-releasing hormone, unleashes a series of biochemical reactions in the body. Soon girls will notice a swelling of tissue around the nipples. (Menstruation usually begins a year or two later.) In boys, the penis and testes start to grow larger...
Girls younger than seven or those whose puberty seems to be accelerating--producing, for example, adult-size breasts--may require medical treatment. Sometimes the problem is a tumor. Other times there appears to be no physical cause. Current treatment consists of monthly injections of a powerful gonadotropin-blocking drug called Lupron. Cost: $6,000 to $10,000 a year. Opting for treatment is not a decision to be taken lightly, so if your doctor recommends such a course, get a second opinion...
...experimental treatment with perhaps fewer ill effects involves a synthetic substance called nafarelin, similar to gonadotropin-relea sing hormone. Normally GnRH is released in bursts by the hypothalamus gland, eventually triggering the process of ovulation. But "if the GnRH stimulation is given continuously instead of in pulses," explains Dr. Robert Jaffe of the University of California, San Francisco, "the whole (ovulatory) system shuts off," and the endometrial implants "virtually melt away...