Word: gramicidin
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...Gramicidin, a drug extracted from soil bacteria and easily confused with penicillin, is also recommended as a wound dressing but is extremely dangerous if it gets into the blood stream...
...Rezende admits that surgery of human nerves is unlike experiments on animals because the wound is often infected. But he believes that new drugs such as the sulfonamides and gramicidin (TIME, Nov. 17, 1941) will decrease this difficulty and should make grafting and gluing of nerves possible in the military surgery of World...
...Gramicidin. Three years ago, Dr. Rene Jules Dubos of the Rockefeller Institute discovered a germ-killer brewed by bacteria that live in the soil (TIME, April 15, 1940). A product of chemical warfare between germs, the brew, called gramicidin, overcomes certain streptococci, staphylococci, pneumococci. In tests on animals and humans it is from 1,000 to 100,000 times as strong as sulfanilamide in healing local infections. One-millionth of a teaspoonful, as much as a drop of mist, is enough to protect a mouse from 10,000 fatal doses of pneumococci...
Trouble with gramicidin is that it also destroys red blood cells, once it circulates in an animal's system. Last week Drs. Charles Henry Rammelkamp Jr. and Chester Scott Keefer of the Boston University School of Medicine reported a hopeful experiment with gramicidin. Instead of injecting it into the blood stream they trickled a few drops of gramicidin right on the wounds of several patients with ulcers and skin diseases. One patient who had a leg ulcer for 15 years was cured in three weeks. The others recovered even more rapidly. But the doctors made it clear that...
...gave the world sulfanilamide. as a great benefactor of chemotherapeutical medicine. Starting with a hunch that there must be agents in the soil capable of breaking up almost anything organic, piling up experiments year after year. Dr. Dubos recently told how he isolated from soil bacilli a substance called "gramicidin," which-in experimental animals-kills pneumococci of five kinds, streptococci, diphtheria bacilli, and other "gram-positive" (blue-staining) germs, possibly including the tubercle bacillus (TIME, April...