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...drugs provided relief to 60% to 80% of patients, but they also caused serious side effects, including sluggishness, weight gain and occasionally death from overdose. The ground was ripe for a better pill, and it wasn't long before scientists produced a new, highly targeted class of antidepressants, led by Prozac, which hit the U.S. market in 1987, followed by Zoloft in 1991 and Paxil in 1992. Instead of blanketing a broad range of brain chemicals, the drugs - known as selective serotonin reuptake inhibitors (SSRIs) - zeroed in on one: serotonin, a critical compound that ferries signals between nerve cells. SSRIs...

Author: /time Magazine | Title: Antidepressants | 1/7/2010 | See Source »

Suddenly, every aspect of the intelligence community's work in Afghanistan is being called into question. According to a report, made public--remarkably--by Major General Michael Flynn, military intelligence has been "ignorant" about the local power structures in combat areas, imperiling U.S. troops on the ground. And it is likely that the attack on FOB Chapman will spill over into the efforts to train the Afghan army and police--which was always an iffy proposition and now faces a massive security question: How many of these trainees are actually reporting to Mullah Omar and bin Laden? After eight years...

Author: /time Magazine | Title: The CIA Double Cross: How Bad a Blow in Afghanistan? | 1/7/2010 | See Source »

...planning to go to a tropical island this weekend with my Brazilian lover, too ... but then there was all that traffic.") There was no denying, however, that she was a vibrant woman on a cool adventure, with stories to tell. The pressure to return to that fertile ground must have been enormous. Just as she was sentenced to marrying, she was sentenced to sequel writing. (See questions and answers about retirement...

Author: /time Magazine | Title: After Eat, Pray, Love: Fret, Mull, Marry | 1/6/2010 | See Source »

...fathers in the study, 166 said they had started smoking before age 11 - just as their bodies were preparing to enter puberty. Boys are genetically isolated before puberty because they cannot form sperm. (Girls, by contrast, have their eggs from birth.) That makes the period around puberty fertile ground for epigenetic changes: If the environment is going to imprint epigenetic marks on genes in the Y chromosome, what better time to do it than when sperm is first starting to form...

Author: /time Magazine | Title: Why Your DNA Isn't Your Destiny | 1/6/2010 | See Source »

Pizer says groups like hers had argued against testing these issues now in federal court, but have since helped with trial preparation. "We very much hope that Ted [Olson] is right that he has the votes to prevail against Prop 8, whether or not new constitutional ground is broken and regardless of which appellate court has the final word in the [San Francisco] case. And we've been doing everything we can to help the trial team prepare, as we're all passionately committed to victory both in this case and in the longer-term, national struggle...

Author: /time Magazine | Title: A Gay-Marriage Lawsuit Dares to Make Its Case | 1/5/2010 | See Source »

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