Word: gutting
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...order to push yourself away from the table. Then came the discovery in 1995 of genes that regulate leptin, the hormone that controls how much fat your body stores. Since then, scientists have identified dozens of compounds related to weight, some released in the brain and others in the gut...
Scientists are channeling their efforts toward two main targets: the feeding center in the brain, which is supposed to tell the body when to eat and how much, and the myriad signals that originate in the gut and then flow into the brain, triggered by the amount of food you eat. These messages order the body to burn calories right away or store them as fat for later...
Even more exciting is a compound that appears to attack obesity through both the brain and the gut. Called rimonabant, and developed by Paris-based Sanofi, it is entering the final stages of human testing. Like Axokine and leptin, rimonabant was designed to make the body feel full. But scientists were pleasantly surprised to find that it also lowered triglyceride levels 15% and raised good cholesterol 22%--far more than would have been expected from weight loss alone. There is also evidence that patients on rimonabant may become more sensitive to the action of insulin, which can halt the progression...
...freaky jolts. Fans of the films of David Cronenberg, such as "The Fly" and "Rabid," with their themes of bodily corruption, will see his influence on Ito's work. His brilliant drawings only become more outrageous as the story goes on, searing your brain with fantastically detailed moments of gut-puking carnage and nightmarish surreality. At one point Tadashi encounters a circus taken over by the germ that keeps going about its business - a seeping, rotting parody of its once jubilant self. One complaint: although the entire book is in English, including the sound effects, it has been printed right...
...Bush's overheated sense of good vs. evil has been reinforced by the intellectual fantasies of neoconservatives like I. Lewis Libby and Paul Wolfowitz, who serve Bush's two most powerful advisers, Dick Cheney and Donald Rumsfeld. It was neoconservatives who provided the philosophical rationale for the President's gut response to the evildoers of Sept. 11: a grand crusade--yes, a crusade--to establish democracy in Iraq and then, via a benign tumbling of local dominoes, throughout the Middle East. Those who opposed the crusade opposed democracy. Those who opposed the President coddled terrorists (according to recent G.O.P...