Word: hafler
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...they have never been able to figure out why the body turns on itself, and they hope these new genes may offer a clue. "This is by no means the final, whole answer, but we've gotten an incredible glimpse into the cause of the disease," says Dr. David Hafler, professor of neurology at Harvard Medical School and Brigham and Women's Hospital and an author of one of the papers, which appears in the New England Journal of Medicine. In the other reports, published in Nature Genetics, two independent research teams confirmed the role of one of the genes...
...decades, MS researchers have been forced to make their best guess as to what causes the disease, which affects 300,000 Americans, mostly women, between their 20s and 40s. Since 1990, thanks to work done in Hafler's lab, however, they've known that MS sufferers have hyperactive T cells - cells that cruise the body looking for bacteria, viruses and other pathogens - a condition that triggers an inflammatory response and destroys the protective myelin sheath around nerve cells in the central nervous system, which connects the brain and body. This can lead to gradual nerve damage and weakening...
...better answer, leading MS scientists in the U.S., including Hafler, teamed up with researchers in England and formed the International Multiple Sclerosis Genetics Consortium in 2002. The plan was to take their genetic study to the next level. So, they pooled their resources and examined the entire genomes of more than 2,000 MS sufferers, their families and control subjects. "People had been studying the genetics of MS for 20 years, and nothing had come out of it," says Hafler. "I felt we needed a genetic roadmap to show us what pathways to study that would help to explain...
...think we truly know that Kerry can lead the country in a direction in which we believe we want to be moving,” Hafler said. “I think there’s an intellectual rigor when we look at their platforms and I think we carefully analyze them and we think that Kerry can lead the country...
...Hafler viewed the disparity in donations differently...