Word: haloperidol
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Dates: during 1990-1999
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...schizophrenia field was reborn in 1989, when the U.S. Food and Drug Administration approved a remarkable drug, clozapine (brand name: Clozaril). Made by the Swiss pharmaceutical firm Sandoz, Clozaril was aimed at patients who did not benefit from other drugs. While traditional antipsychotic drugs such as chlorpromazine (Thorazine) and haloperidol (Haldol) work by blocking dopamine receptors, Clozaril appears to bind to serotonin receptors as well. "It is what we call a dirty drug," says Mount Sinai's Davis. "It probably binds to a whole bunch of receptors. We used to think that was a bad thing. Now we think that...
...1950s noticed that Thorazine, then administered as a sedative, quieted ravings and hallucinations among soldiers awaiting surgery. That prompted a Paris psychiatrist to try the drug on schizophrenics. Thorazine calmed patients and reduced their symptoms. It was quickly proclaimed a miracle drug. Thorazine and related drugs such as haloperidol, fluphenazine and thiothixene soon eclipsed the brutal treatments previously in vogue: lobotomy, primitive electroshock and artificially induced insulin shock. Over the next two decades, nearly half a million patients were discharged from state hospitals in the U.S. and hundreds of thousands more from hospitals in Europe...