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With the new gene in hand, the researchers should be able to churn out at will the protein for which it provides the genetic blueprint. That protein, they believe, is telomerase's most important building block. "For us," exults Calvin Harley, Geron's chief scientist, "it's like having access to an organism's brain...

Author: /time Magazine | Title: THE IMMORTALITY ENZYME | 9/1/1997 | See Source »

...fashion has joined Hollywood and sports among the great public spectacles of our time, Versace was one big reason why. And if Miami Beach is now a laboratory of instant gratification, full of clubs and in-line skaters and muscle guys with deltoids like the gas tanks on a Harley--in some measure that was Versace's doing too. Six years ago, when the city was threadbare, he fell in love with it, and soon began converting a hotel and a crumbling apartment building into his comically scrumptious mansion, one of his four homes around the world. And where Versace...

Author: /time Magazine | Title: TAGGED FOR MURDER | 7/28/1997 | See Source »

...priest who sparked hope in the bleak aftermath of Detroit's 1967 race riots by founding a hugely successful organization to feed and train the urban poor; of complications related to cancer; in Detroit. The once shaggy-haired cleric led Focus: HOPE while zipping about his parish on a Harley-Davidson...

Author: /time Magazine | Title: Milestones Jun. 9, 1997 | 6/9/1997 | See Source »

Since telomerase keeps these tenacious cells going, is it reasonable to assume that the same enzyme could be used artificially to help mortal cells--and the body itself--exceed their programmed life-span? At Geron Corp., a San Francisco-based biomedical firm, biologist Calvin Harley is trying to find out. Harley, who collaborated with Greider on her later telomere work, is looking for the genes that direct telomerase production, believing he might be able to manipulate them so that the spigot for the enzyme can be turned on and off at will. "I think we are going to see fundamental...

Author: /time Magazine | Title: CAN WE STAY YOUNG? | 11/25/1996 | See Source »

...even as Harley begins his search, other genes implicated in aging have already been flushed out of hiding. At McGill University, Hekimi's long-lived nematodes have helped expose a few of them. Hekimi created his little uberworms by crossing and recrossing individuals that lived longer naturally, slowly extending the life-spans of later generations. He then searched the animals' chromosomes until he found the mutated gene responsible, a gene he dubbed Clock-1. "The Clock-1 gene is critical in setting life-span," Hekimi says. "More important, with cloning and genetic mapping, we were able to determine just which...

Author: /time Magazine | Title: CAN WE STAY YOUNG? | 11/25/1996 | See Source »

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