Word: harren
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Dates: during 2000-2009
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Similarly, Harren Jhoti left pharmaceutical giant Glaxo Wellcome (now GSK) in 1999 when he realized that his unconventional idea of how to find new drugs to attack disease-causing proteins might never be realized unless he pursued it himself. He founded Astex, based in Cambridge, England, so he could develop his own flexible approach to molecular research. He calls it "fragment based," because rather than throwing an entire proposed drug molecule at the target protein, he throws just pieces at a time...
...Harren Jhoti, too, made a discovery that had eluded better-funded corporate researchers. In October 2002, Jhoti and his colleagues at Astex discovered in their Cambridge lab a chemical that bound to a protein called beta-secretase (Bace), which researchers had identified as a possible cause of Alzheimer's disease. The chemical was just a fragment of what could eventually become an Alzheimer's-conquering drug. But it represented a big step in the quest for a Bace-targeting substance, which drug giant AstraZeneca had been seeking for years; the firm enlisted Astex's help. "AstraZeneca worked...
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