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...Further studies on HIF] would allow us to take new directions in attempts to find ways to treat hypertension," he says. Haupert is also hopeful that hypertension may be used as a model to study other diseases involving the cardiovascular system...

Author: By Virginia A. Triant, | Title: Zeroing in on the Causes of Hypertension | 11/30/1993 | See Source »

...concepts behind the search for what eventually turned out to be HIF, according to Haupert, have been developing for more than two decades. Twenty years ago, scientists speculated that an unknown substance increased sodium excretion in animal models. During the '60s, the substance was believed to be a circulatory factor--present outside of the cell--which caused cells to excrete additional sodium...

Author: By Virginia A. Triant, | Title: Zeroing in on the Causes of Hypertension | 11/30/1993 | See Source »

When research failed to yield positive results, some scientists began to ponder the problem from a different angle--"a much more philosophical point of view," according to Haupert...

Author: By Virginia A. Triant, | Title: Zeroing in on the Causes of Hypertension | 11/30/1993 | See Source »

...only known cell pump regulator at that time was digitalis, a plant substance currently used as a drug to treat heart conditions. But Haupert says he questioned the idea that only once substance exists to control such an integral aspect of homeostasis...

Author: By Virginia A. Triant, | Title: Zeroing in on the Causes of Hypertension | 11/30/1993 | See Source »

...Haupert and scientists at the MGH reasoned that an analogous substance could be present in mammalian cells, and began in 1977 to target organs in which the pump plays a key role...

Author: By Virginia A. Triant, | Title: Zeroing in on the Causes of Hypertension | 11/30/1993 | See Source »

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