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Merck, which funded much of the research and has licensed Chiron's technology for the new product, will sell the hepatitis B vaccine under the name Recombivax HB. The vaccine will join a handful of pioneering products of recombinant DNA, or gene splicing, that have reached the market, including human insulin (1982), human growth hormone (1985) and alpha interferon (1986). The FDA approval of Recombivax HB is expected to give a big boost to the public image of an industry that has been more promising than profitable. Said Chiron President Edward Penhoet: "We think this vaccine will usher...
Recombivax HB is made by inserting a gene from the hepatitis B virus into yeast. The yeast cells then multiply rapidly and manufacture large amounts of a protein from the virus. This protein forms the basis of the new vaccine, which triggers an immune reaction when injected into humans...
...somewhat less desirable because it must be made from the blood of infected individuals. Though there have been no reported cases of infection stemming from Merck's blood-based vaccine, the possibility that diseases such as AIDS and hepatitis B could be transmitted in blood products always exists. Recombivax HB eliminates that possibility, however slight...
...time being, both vaccines will cost patients $110 for a course of three inoculations. After the development costs for Recombivax HB are recovered, however, it may become cheaper than the blood-based alternative. Reason: the prolific yeast will make it easier to mass-produce Recombivax HB...
...Acton, Mass. 25 Joel Seay SE Fountain Valley, Calif. 26 Al Fletcher DB Waterford, Conn. 27 Brian Bergstrom CB Swedesburg, Iowa 28 Paul Arnett K Atlanta, Ga. 28 Bill Hyland FS Foxboro, Mass. 29 Joe Connolly SE Selbyville, Del 30 Brian Cooke FB Hingnam, Mass 31 Rufus Jones HB Memphis, Tenn 32 Jim Lowe WB Springfield, Pa. 33 Mark Vignali RB Uniontown, Pa. 34 Dave Landau QB Rye Neck, N.Y. 35 Chris Tillo FB Centerville, Mass. 36 Chris Ridout FB Rolling Hills Estates, Calif 37 Brian O'Neil FB Reading, Mass. 38 Terry Denson HB Webster, N.Y. 39 Chris Hannan...