Word: heart
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Dates: during 1990-1999
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...huskier look, and often that huskiness is not fat. [But] there are people we all know who used to be fat, then permanently changed their life-styles, and are now thin." says Dr. David Heber of the UCLA Center for Human Nutrition. Obesity most definitely increases risk of heart disease, Heber adds...
...spectacular listening. Just hear her morose, lyrical ramble over Erlandson's spare guitar on Northern Star; or the line in the enchanting Malibu when she breaks the song's sweet spell, growling, "And I knew/ Love would tear you apart/ Oh and I knew/ The darkest secret of your heart." This CD has pop skin, but it bleeds punk...
...years ago, you could hardly pick up a newspaper or a magazine (including this one) without catching the buzz about a pill called Redux that was going to revolutionize the way Americans lose weight. Then last summer doctors noticed an alarming number of heart-valve problems in their patients who took Redux or its chemical cousin fenfluramine, prompting the recall of both drugs. Now comes word, from three studies published in last week's New England Journal of Medicine, that the heart problems may not be as serious as was first feared--at least for patients who took the pills...
Just how relieved you feel, however, depends on how carefully you read the reports. Taken together, the studies do, after all, confirm that taking Redux or fenfluramine (whether alone or in combination with phentermine as part of the wildly popular fen/phen regimen) can trigger an abnormal thickening of the heart valves, which may cause a backward flow and pooling of blood. Cardiologists pay special attention to such "leaky valves" because they are particularly vulnerable to infection, may predispose you to congestive heart failure or may signal the need for surgery...
Under the best circumstances--in which patients took Redux at the recommended dose for the shortest period of time, 11 weeks--changes in heart valves appeared to be not too serious. The longer that patients took the diet pills or the higher the dose, however, the greater the problems. (In the case of Redux, that meant taking more than 30 mg a day; for fenfluramine, more than 60 mg a day.) One study found that the risk of developing a heart-valve problem jumped 10- to 20-fold...