Word: heart
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Researchers at Beth Israel Deaconess Medical Center have discovered a new diagnostic test for a severe heart condition that now often goes undetected before causing sudden death...
Previous diagnostic tests relied on characteristic changes that occur when the disease is already far advanced, at which point the patients are near death or require a heart transplant, Saffitz said...
...diagnostic test consists of obtaining a sample of tissue from a heart biopsy and then looking for a specific protein that the researchers found exists in smaller quantities in patients with ARVC, said Angeliki Asimaki, the study’s lead author and a research fellow at the Medical School...
Most of the mutations that cause ARVC are in genes encoding components of a type of cell junctions called “desmosomes,” which are particularly abundant in tissues that experience great mechanical force, such as the heart...
...researchers found that every sample from a patient with ARVC had less plakoglobin and that in other types of heart disease plakoglobin was normal...