Word: heart
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...aftermath of reports concluding that these targets do not cut the risk of heart disease in diabetes patients, and in some cases may even do harm, researchers are struggling to make sense of the seemingly counterintuitive data, and physicians are trying to figure out how to incorporate the findings into their practice...
...data come from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, a three-part federal study launched a decade ago to investigate whether the aggressive lowering of those key risk factors - blood sugar, cholesterol and blood pressure - would reduce heart risks in diabetes and prediabetes patients. Two years ago, the blood-sugar arm of the study was terminated, when people who drastically reduced glucose levels ended up having a higher overall mortality rate than those not receiving such intensive therapy. See how to prevent illness...
...trial - one in which patients were treated with blood-pressure-lowering drugs and another in which they received statins to reduce cholesterol and fibrate medications to slice their trigylceride levels - showed the same trend, finding that aggressive drug treatment did little to reduce the volunteers' risk of developing heart problems...
...blood-pressure study, involving about 4,700 diabetes patients, researchers lowered the participants' systolic blood pressure to either below 120 or 140 using a combination of drugs. But lower blood pressure did not lead to fewer heart attacks or heart-related deaths, and patients taking more drugs to keep their blood pressure under the lower target were more likely to suffer severe side effects...
...statin and fibrate study, about 5,500 patients with diabetes and at least one other health problem were given cholesterol-lowering statins; half were also given a triglyceride-lowering fibrate. There was no difference in heart-attack and stroke rates between the groups. (See the top 10 medical breakthroughs...