Word: heartful
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Dates: during 1980-1989
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...levels of men over the age of 35 fall well into the borderline-high-risk area. More than a third of American men between the ages of 45 and 64 are in the high-risk category. Because of differences in hormones, premenopausal women run a low risk of developing heart disease. In later years, though, this advantage is lost, and women between 55 and 64 have significantly higher total cholesterol levels than men the same age. The dangers of high readings are evident: the chance of a heart attack has been found to double with every 50 mg/dl increase...
Michael Bruno of Cincinnati is one heart-disease patient who has benefited from drug therapy. A 55-year-old former printing-plant foreman, Michael and his brother Daniel, 58, a retired barber in Canonsburg, Pa., have a genetic disorder that results in very high levels of LDL and low levels of HDL. Daniel has suffered a heart attack, and both brothers have had bypass surgery. Now the Brunos are on low-saturated-fat diets and are taking lovastatin. In addition, Michael is taking gemfibrozil. Since the brothers started their programs, Michael's total cholesterol has fallen from...
Even though HDL's relationship to coronary heart disease was first noted in 1951, many people are still not being advised by their doctors to raise their good-cholesterol levels. The reason, says Dr. Robert Levy, president of New Jersey's Sandoz Research Institute, is that there is no absolute proof that raising HDL alone can lower a person's risk of heart disease. No convincing body of evidence from animal studies has yet demonstrated the value of raising HDL, and no clinical trial to date has specifically targeted humans with low HDL. "Much the same question existed...
...derive synthetic HDL particles from natural HDL made in the body. At the Rogosin Institute, researchers are injecting this compound into rabbits to see if raising HDL protects them against atherosclerosis. Should such experiments succeed, it is conceivable that synthetic HDL could one day become an effective treatment for heart patients. Rogosin's Gordon notes, however, that this research "is still years away from clinical application...
...study showed that obstructed arteries benefited most from decreased LDL. Lower levels of triglycerides, he found, may also play an important role, a possibility that has emerged from other studies as well. At Baylor College of Medicine in Houston, Dr. Antonio Gotto Jr. discovered that his heart-bypass patients "almost without exception" have lower levels of HDL and slightly higher levels of triglycerides than people without heart disease. One theory is that excess triglycerides somehow mark HDL particles for elimination by the liver. When this occurs, says Gotto, "there is this Pac-man in the liver chewing...