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...chromosomes. All chromosomes have protective caps at either end called telomeres. Each time a cell replicates itself (as it does before it dies), the telomeres shorten, like plastic tips fraying on the end of shoelaces. Shortened telomeres have been linked to a host of age-related illnesses such as heart disease and certain cancers. (Scientists have yet to study whether telomeres influence a person's appearance.) Last year's Nobel Prize for Medicine was awarded to three American scientists for their work in the field, and many scientists now believe that telomeres are the closest we may come to identifying...

Author: /time Magazine | Title: Scientists Get Closer to Understanding Why We Age | 2/15/2010 | See Source »

Spector and Samani say that understanding the components that determine telomere length may one day help researchers devise new treatments for age-related diseases, particularly heart disease (the study was partially funded by the British Heart Foundation). "I see in my practice 80-year-olds with healthy coronary arteries and 40-year-olds with heart disease. We may be on our way to explaining the genetic component in the explanation for why this is so, and so expanding our knowledge of the disease and how to treat it," Samani says. (See the top 10 medical breakthroughs...

Author: /time Magazine | Title: Scientists Get Closer to Understanding Why We Age | 2/15/2010 | See Source »

...Samani also says the telomere research offered no quick fixes and that telomere-based treatments were still a long way off. The reason for this is that telomeres - while potentially lowering the risk of heart disease - play a role in the development of cancer cells. "We all probably develop cancer cells that don't get past a few replications because of the effect of normal telomere shortening. If you make cells immortal by allowing them to replenish their telomeres, you may raise the risk of many nasty cancers considerably...

Author: /time Magazine | Title: Scientists Get Closer to Understanding Why We Age | 2/15/2010 | See Source »

Greek Prime Minister George Papandreou has put tax reform at the heart of his austerity plan, and says his government is serious about fixing the roots of his country's current economic predicament. He says Greece will tackle its deficit without the deep government-wage or job cuts that other heavily indebted European countries, like Ireland, Spain and Portugal, have recently announced. Instead, Athens will pursue tax evaders. "Greece's problems," Papandreou told journalists at a press conference marking his first 100 days in office, "are due to waste, corruption and lack of respect towards...

Author: /time Magazine | Title: Taxing Times in Greece | 2/15/2010 | See Source »

...budget Bollywood films as well as small independent films in the U.S., Europe and India. Khan's specialty is adding a layer of unexpected depth and tenderness to an otherwise opaque character - the interrogator in Oscar winner Slumdog Millionaire, a Pakistani police captain in A Mighty Heart, the remote immigrant father in The Namesake. Danny Boyle, the British director of Slumdog Millionaire, believes that as other Western studios try to replicate the film's success with movies set in India, Khan will be even more in demand - quintessentially Indian, and yet something else besides. "He is a touchstone connecting...

Author: /time Magazine | Title: Keeping It Real | 2/15/2010 | See Source »

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