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Gewirtz's team, including researchers at Emory, Cornell University and the University of Colorado at Boulder, became intrigued by the relationship between gut bugs and weight when they noticed that lab mice lacking a certain protein had more of the bugs than other animals and were about 15% heavier. These mice also had a higher level of inflammation, which the authors explain in their paper published online Thursday in Science Express is what may account for the extra weight. Inflammatory signaling can promote a condition called metabolic syndrome, which causes weight gain, high blood pressure and high cholesterol levels...

Author: /time Magazine | Title: A Hidden Trigger of Obesity: Intestinal Bugs | 3/5/2010 | See Source »

...immune system, making them incapable of rejecting foreign cells and bacteria. When these animals received the teeming gut world of the TLR5-deficient mice, they too began eating more and developed the same metabolic-syndrome symptoms that their donors had. In other words, the obesity profile of the heavier mice had been transferred to normal mice. "So, applying the logic to humans," says Gewirtz, "we know that to gain weight and become obese, [it] requires you to eat more. The question is, Why do people eat more? Our results suggest that one reason people might be eating more is because...

Author: /time Magazine | Title: A Hidden Trigger of Obesity: Intestinal Bugs | 3/5/2010 | See Source »

...similar fashion, “Here Today, Gone Tomorrow,” marks the band’s sole instance of musical experimentation. In a departure from the soft rock which defines much of the rest of the album, this track is marked by a heavier bass line and more reverb. Much like the rest of the album, however, the lyrics still leave a little to be desired—“You’re all talk and nothing to say / We don’t want, don’t want what you’re giving...

Author: By Chris A. Henderson, CONTRIBUTING WRITER | Title: Lifehouse | 3/2/2010 | See Source »

...certain extent, mounting sovereign debt is a natural outcome of the recent recession. As in any downturn, tax revenues shrank but government spending increased to stimulate sagging economies. The result: budget deficits and more borrowing. Expensive banking-sector bailouts made the burden even heavier. That's not automatically dangerous. There is no particular level of debt that acts as a trip wire and tosses an economy into crisis. Different economies can bear different levels of government debt, depending on their ability - real or perceived - to finance it. While Greece's small and uncompetitive economy is struggling to stay afloat, Japan...

Author: /time Magazine | Title: Weighed Down | 3/1/2010 | See Source »

Touch of Evil That's partly because Teddy feels estranged from the island's less ethereal inhabitants. DiCaprio makes Teddy sometimes cagey-witty, sometimes stupid (he keeps mispronouncing escape as excape). Gruff and heavier than usual, with a few days' beard, he could be channeling Orson Welles' wily lawman in Touch of Evil. The onetime heartthrob from Titanic has always been a shifty character actor in a movie star's body. A star performance here would give the audience someone to root for; DiCaprio instead provides them with the spectacle of a creature fighting to creep toward a freedom that...

Author: /time Magazine | Title: Shutter Island: Engrossing, Not Enthralling | 3/1/2010 | See Source »

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