Word: hemophilia
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Dates: during 1950-1959
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...world's fourth known family case of female hemophilia was reported in Seattle by two University of Washington internists. Thomas Newcomb and Martin Matter. Their discovery, confirmed by standard tests: a seven-year-old girl who reversed the usual transmission pattern (mother-carrier-to-son) by inheriting the disease from her father's side of the family.* A paternal grand-uncle is known to have had bleeding problems in childhood; there is no maternal hemophilia history. The girl was hospitalized after loosening baby teeth caused excessive bleeding, is now responding favorably to standard treatment (i.e., injection of fresh...
...blood to the Red Cross has become a pretty lush operation. Three years ago, the local blood collecting agency was content to set up a half dozen beds on the ground floor of P.B.H. A small staff serviced the beds, made examinations so cursory they could scarcely have caught hemophilia, and dispensed bottled Coca-Colas to drained donors. The whole process took about 20 minutes...
According to common belief, only men can be victims as well as transmitters, and women can only be transmitters of hemophilia.* Common belief is almost, but not quite, true. By Mendelian laws of inheritance, the daughter of a father-bleeder and a mother-carrier can be a bleeder. Doctors believed that such a child would die in the womb. . The British doctors report that a patient of 24 who visited a Manchester clinic during her first pregnancy had a history of easy bruising and free bleeding. Nevertheless she had a natural delivery and went home ten days later. Then...
...patient's family tree shows clearly that she is the offspring of a father-bleeder and a mother-carrier. Her blood meets all the tests for true hemophilia. The doctors are sure that they have found a case to fit the classic Mendelian pattern. But they have no idea how she came to be born alive, or how she survived the hazards of growing up, menstruation and pregnancy...
...Another common belief, that hemophilia is "the curse of the Habsburgs," is unfounded. It was a lethal gift to the royal families of Europe from Britain's Queen Victoria. Of her four sons only the youngest, Leopold, was a bleeder, died at 31. But two of Victoria's daughters, Alice and Beatrice, carried the disease to their German offspring. Through one of Alice's daughters, it passed to the Czarevitch Alexis (murdered by the Bolsheviks in 1918); through Beatrice's daughter to sons of Spain's Alfonso XIII...