Word: hemophilia
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...John C. Norman '50, associate in Surgery, is the head of a project at Boston City Hospital that for the first time has succeeded in curing a dog of hemophilia...
Norman and his associates--among whom is Dr. Victor C. Covelli, Research Fellow in Surgery--earlier discovered the crucial role of the spleen in producing Factor VIII, a substance whose presence in the body prevents hemophilia...
Known as "the disease of kings," hemophilia is a hereditary disease, almost always limited to males, in which blood takes a very long time to coagulate. Normal blood takes five to fifteen minutes to form a clot, but the blood of hemophiliacs may take many hours...
What Norman found is that Factor VIII is produced by the spleen. In the past the treatment for hemophilia has been the injection of Factor VIII into the hemophiliac. Te new method is to replace the defective spleen of the hemophiliac with a healthy...
...hemophilia research has been carried out in the Sears Surgical Research Laboratories in the Cardiovascular Division, of which Norman is director. The project is financed mainly by a grant from the National Institutes of Health...