Word: hemophilia
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Juan Carlos was an unlikely monarch. His branch of the Bourbon dynasty was impoverished and living in Rome. It was eligible for the kingship only because the direct line was tainted with the hemophilia gene inherited from Britain's Queen Victoria. Needy and apparently pliant, he thus became the acceptable heir to Francisco Franco, military dictator of the kingless kingdom of Spain. At Franco's 1975 death, Juan Carlos, above, at his 1962 wedding, took the throne. Spaniards expected little. But the King pressed the move to a constitutional monarchy. When militarists opposed it and attempted a coup...
...April 1994 Bodkin started working in Associate Professor of Medicine Kenneth A. Bauer's laboratory on a project funded by a three-year grant, studying the genetics of factor VII hemophilia. One other researcher, Arnaldo A. Arbini, was working with them...
...April 1994 Bodkin started working in Associate Professor of Medicine Kenneth A. Bauer's laboratory on a project funded by a three-year grant, studying the genetics of factor VII hemophilia. One other researcher, Arnold A. Arbini, was working with them...
Wilson expects Phase I trials using AAV to begin later this year, first for the treatment of hemophilia and later for a form of muscular dystrophy, a liver metabolic disease and retinitis pigmentosa, an eye disorder. "It's kind of a new wave," he says...
...ability to cause disease? "We have done 115 such preparations," he says reassuringly, "and to date we have never seen a virus that is capable of infecting new cells." Later this year he plans to ask the FDA for permission to begin a Phase I trial for hemophilia...