Word: hemophiliacs
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...turns out that Hippocrates was right after all. Proof of his accuracy comes from three Mayo Clinic researchers, Drs. Anton Sutor, E.J. Walter Bowie and Charles Owens Jr., who used hemophiliac volunteers to determine the effects of cold on bleeding. Their experiments were simple. Making small (1 mm.-long by 1 mm.-deep) wounds in their subjects' arms, they tried chilling first the wound itself, then the wound and the surrounding area, and finally the surrounding area alone. Each time they collected the blood in special plastic cubes and analyzed it to determine clotting time...
When menaced by a revolver-brandishing intruder in his new play, Woody Allen implores, "Don't pull the trigger. I'm a bleeder!" Though no shot is fired, Play It Again, Sam is riddled with laughs. Apart from being a hemophiliac, Allen's latest hero, Allan Felix, is an exposed ganglion of neuroses, guilts and self-recriminations. He looks like a wilted scarecrow that would cringe at a sparrow's chirp. He has so many psychological hang-ups that he makes playgoers feel positively healthy, which may be why they tend to love...
...What the hemophiliac's blood lacks, because of a genetic defect transmitted from mother to son, is a clotting protein known as antihemophilic factor (AHF) or globulin (AHG), also called Factor VIII. Because of this deficiency, the hemophilia victim lives in constant danger of severe bleeding from the most minor wound, such as a finger cut or a tooth extraction. Even with no external injury, he may bleed internally after a bump or a stumble. This is especially likely to happen inside his joints, causing arthritis with progressive deformity and disability...
...frozen state, this cryoprecipitate kept indefinitely and could be quickly processed for intravenous infusion in a solution averaging ten to 20 times the potency of plasma. But infusion took up to an hour, and the hemophiliac usually had to go into a hospital to get it. The material could be extracted from only the freshest of plasma. Even the short delay between collection by a mobile blood unit and delivery at a blood center was long enough to destroy or damage...
...says Raatz, "I can do much more work and stay on the trial calendar. Clients have more confidence in me, now that I'm available regularly. No one who is not a hemophiliac can imagine what a relief it is to be able to work on schedule." His wife Joan recently bore the Raatzes' second baby. Like the first, it was a boy. And by a Mendelian pattern of inheritance, a hemophiliac cannot transmit the disease...