Word: hench
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Dates: during 1940-1949
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...William S. Tillett and L. R. Christensen of the New York University School of Medicine, jointly, for discovering and purifying streptokinase and streptodornase, enzyme substances effective against clots in the body (e.g., pus or dead tissue) which delay healing. ¶Drs. Edward C. Kendall and Philip S. Hench of the Mayo Clinic, jointly, for work which led to the development of the dramatic easer of arthritis, cortisone (TIME...
Chicken or Egg? Rheumatic patients carry in themselves the cure as well as the cause of the disease, say Mayo's Drs. Philip S. Hench and Edward C. Kendall. The problem: how to wake up the dormant curative powers in the body. Drs. Hench and Kendall have succeeded in doing it dramatically but temporarily with two hormones: cortisone, originally called compound E,* and ACTH (TIME, May 2). But they were cautious in their report, warned that the hormones are still extremely scarce and that it is too early to tell how safe the long treatment will...
...After Hench and Kendall's discoveries at the Mayo Clinic that Compound E was effective in the treatment of rheumatoid arthritis, studies were made of the prolonged effect of ACTH on rheumatoid arthritis patients," Dr. Thorn said...
Substance X. In 1929 Dr. Hench noticed that men & women with arthritis suffered less pain when they had jaundice. Women suffered less when they were pregnant. He noticed too that patients who had surgical operations got better for a while (during an operation, the adrenal cortex, or outer layer of the adrenal gland, is stimulated...
...early as 1941, Drs. Hench and Kendall speculated that an unknown "anti-rheumatic substance X" might be a hormone from the adrenal glands. In 1946, with the help of Merck & Co. chemists, they developed a compound from the adrenal glands of cattle. It was called Compound E (full name: 17-hydroxy-11-de-hydrocorticosterone). Compound E belongs to the steroid group of body chemicals. So do the sex hormones (a link with relief during pregnancy) and some bile products of the liver (a link with jaundice). Compound E was obtained later from an element of bile. Seven months ago Mayo...