Word: henderson
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...Kevin Eggan at the Harvard Stem Cell Institute and Christopher Henderson at Columbia University, the 13-person team reported online today in Science Express that they had generated motor neurons from the skin cells of two elderly patients with a rare form of ALS, or Lou Gehrig's disease, a progressive neurodegenerative condition. The new study marks an important first step on the road toward real stem-cell-based therapies, and also answers several plaguing questions about the pioneering stem-cell technique known as induced pluripotent stem cell, or iPS, generation...
Researchers also questioned whether iPS would work with delicate cells from older people or with cells taken from patients with disease (Yamanaka used skin cells from healthy middle-aged people in his study). Eggan and Henderson tackled both issues at once, by working with cells from two siblings, ages 82 and 89, who both had ALS. It turned out that generating iPS cells from older patients proved no more difficult than growing them from younger ones, says Eggan. "This study puts those issues definitively to rest," he says. "It opens the door to being able to make patient-specific stem...
There are other, more immediate payoffs of the new study. For one thing, it gives researchers a better understanding of how ALS progresses. Because the new nerve cells have the same genetic makeup as the patients' own diseased cells, Henderson says, they may very well develop signs of the disease in culture, allowing researchers to watch ALS unfold before they eyes. "Our lack of understanding of the disease process is preventing us from developing more efficient cures," says Henderson. "Because the disease is happening in the spinal cord, we don't have access to living samples of neurons undergoing...
...eight- and 16-bar call-and-response choruses, sung out lustily by the saxophones, trumpets and trombones, supported wild improvisational flights by Goodman, Trumpeter Harry James and Drummer Krupa. The big breakthrough came at the Palomar Ballroom in Los Angeles. ''I called out some of our big Fletcher Henderson arrangements,'' remembered Goodman, ''and the boys seemed to get the idea.'' The crowd stopped dancing and rushed the bandstand. The swing era had begun, and Benny, then and thereafter, was its king. In 1937, he earned $125,000, while President Franklin D. Roosevelt received $50,000; like Babe Ruth...
...good enough for second in the Ivy League. Leading the way for the Crimson was freshman Ellen Macadam, who hit at a .371 clip. The rookie also found success on the base paths. Macadam stole 18 bases, better than everyone in the Ivy League except for classmate Emily Henderson, who ran her way to 28 stolen bases. Henderson was named to the All-Ivy First Team. Harvard was also the League’s top defensive team. Its collective 49 errors were the fewest of any team in the Ancient Eight. And while one of the Crimson?...