Word: heparin
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Dates: during 1940-1949
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Thrombosis, the specialists reported last week, is no longer so dreaded. In the past two years investigators have had notable results with two anti-clotting drugs: heparin and dicumarol. Heparin is a substance in the liver and lungs first isolated in 1916; dicumarol is found in spoiled sweet clover (its anti-clotting property was first discovered when it was found that cattle feeding on it sometimes bled to death). Both drugs prevent clots from forming...
...Heparin acts within a few minutes, but it is expensive and has to be injected every few hours. Dicumarol is cheap and easy to take (in pills), but it takes 24 hours to work. Doctors combine them: heparin for the emergency, dicumarol for longer-range effects...
...drip in the donor's blood. When he had dripped in 100 cc, a safe margin, he nicked the radial artery in the baby's right wrist, attached a tube, let the baby's blood drain out. To keep it flowing freely, he injected anti-clotting heparin...
...severe cases of gangrene resulting from frostbite, there is only one proven remedy: amputation. But the Army last week announced a less drastic remedy that looks promising. Its name: heparin, a well-known anti-blood-clotting substance. Heparin apparently stops gangrene by helping circulation in frozen limbs...
Lange and Weiner thereupon tried heparin injections, found that if given soon enough (within 48 hours after exposure) no gangrene developed. Now they are testing heparin against trench foot, which seems to have about the same effect on red blood cells as frostbite...