Word: heparin
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Dates: during 1980-1989
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...National Institutes of Health and known as TIMI II (for thrombolysis in myocardial infarction phase II trial), involved 3,262 patients who had suffered apparent heart attacks. Within four hours of their attacks, all patients received a powerful clot dissolver, known as TPA (tissue plasminogen activator), along with heparin and aspirin to inhibit blood coagulation. Of the 1,636 patients in the invasive-strategy group, 928 underwent angiography and angioplasty within 18 to 48 hours after their attacks...
...lessen the chances of clots after the five-hour implant operation, doctors gave Drummond low doses of heparin, an anticoagulant; they also lowered the air pressure that drives the mechanical heart to ensure a gentler blood flow and thus reduce the turbulence that damages red blood cells. Unfortunately, the strategy failed to work. But by week's end Drummond had a human heart and was in critical but stable condition...