Word: heparin
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...says has been previously demonstrated on animals, but never before on human beings): a glass tube is fitted into the pulsing ends of a severed artery, bridging the gap so that the wounded member may live until the patient is strong enough to stand an operation. Intravenous injections of heparin prevent dangerous clotting in the tube...
...Link and co-workers went on to get Dicumarol in pure form and then to synthesize it. They found that in the body it makes salicylic acid. Another anticoagulant, heparin, was already on the market. It is also used to keep donors' blood fluid until it can be processed. But it is an expensive extract of ox lung and liver, must be given by injection, and is hard to control. Therefore surgeons (who worry lest a fatal clot undo their work) took up Dicumarol...
...Sano went back to her tissue-culture laboratory at Temple University's School of Medicine and set to work on rats. To make her glue, she took some heart's blood from the rat to be grafted, mixed it with heparin to 'keep it from clotting, separated the cells from the blood plasma, put the plasma in the icebox. She shook the cells up with a special salt solution, separated the salty liquid and kept it, threw the cells away. She calls the salty fluid her "extract." The plasma plus the extract constitutes her glue...
...last few years, thrombi have effectively been treated by heparin-a compound obtained from lungs and livers of animals. Heparin injections cost from $10 to $15 a day, must be dripped into a patient's veins continuously for about two weeks...
Dicoumarin, just as effective as heparin, is far cheaper and may be given by mouth. Dr. Silbert predicted that dicoumarin will soon be used not only as a cure for thrombi, but as a routine preventive in all major operations and confinements. At present it is used in the Mayo Clinic, the University of Wisconsin, and by Drs. Irving Sherwood Wright and Andrew Gabriel Prandoni of Columbia, who made a technical report on it last fortnight...