Word: hesperidin
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Dates: during 1952-1952
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...Sieve calls his pills phosphorylated hesperidin. Plain hesperidin, known for years, is related to so-called vitamin P. These preparations have been tried with indifferent results in a variety of ailments, from kidney disorders and psoriasis to radiation sickness. Hesperidin comes from orange peel and could be made about as cheaply as aspirin in mass production...
...results too nearly perfect. In the first place, Dr. Sieve conceded that in experiments with mice he had had 60% failures. Next, he relied heavily on the theory that the ability of the male sperm to penetrate an ovum depends largely on the enzyme hyaluronidase, and argued that the hesperidin must counteract this enzyme. Actually, say physiologists, there is no proof that hyaluronidase is responsible for penetration of the ovum. Further, Dr. Sieve speculated that the hesperidin helps a layer of cells around the ovum to clump together and keep the sperm out; that too, say physiologists, rests...
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