Word: high
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Dates: during 1980-1989
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...past three years been running a National Cholesterol Education Program. Last year the program set 200 mg/dl as the amount of total cholesterol (essentially LDL plus HDL) above which individuals are considered to be potentially at risk of developing heart disease; those between 200 and 239 are borderline high risk; anyone with a count of 240 or more may be at high risk. The program suggested that everybody should aim for an LDL count of 130 or lower. However, it did not recommend specific HDL targets...
...Americans measure up to these overall guidelines? Rather badly. The mean cholesterol levels of men over the age of 35 fall well into the borderline-high-risk area. More than a third of American men between the ages of 45 and 64 are in the high-risk category. Because of differences in hormones, premenopausal women run a low risk of developing heart disease. In later years, though, this advantage is lost, and women between 55 and 64 have significantly higher total cholesterol levels than men the same age. The dangers of high readings are evident: the chance of a heart...
Michael Bruno of Cincinnati is one heart-disease patient who has benefited from drug therapy. A 55-year-old former printing-plant foreman, Michael and his brother Daniel, 58, a retired barber in Canonsburg, Pa., have a genetic disorder that results in very high levels of LDL and low levels of HDL. Daniel has suffered a heart attack, and both brothers have had bypass surgery. Now the Brunos are on low-saturated-fat diets and are taking lovastatin. In addition, Michael is taking gemfibrozil. Since the brothers started their programs, Michael's total cholesterol has fallen from...
...transport system's delicate balance can be upset by dietary indulgence. Take the case of a mythical glutton called Fred, who regularly gorges on porterhouse steak, French fries, ice cream and other foods high in saturated fats and cholesterol. Fred may feel great, but every time he eats, his bloodstream is flooded with fatty particles called chylomicrons, which transport triglycerides and cholesterol out of the intestines to the rest of | his body. Soon Fred's liver is busy mopping up chylomicrons and is unable to cope with excess LDL in the blood. The surfeit of cholesterol particles then begins circulating...
...actually does have the ability to pull cholesterol out of artery walls, can high levels of HDL reverse the buildup of plaque? There are indications that this may be the case. Last year Dr. David Blankenhorn, director of atherosclerosis research at the University of Southern California, reported on a study in which 162 nonsmoking men who had undergone coronary- bypass surgery were put on a low-fat diet; 80 of them were also treated with niacin and colestipol. Among the drug-treated group, HDL levels increased 37%, while LDL decreased 43% and triglycerides went down 22%. Blankenhorn found evidence that...